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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization.

Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization

by Li Di, Edward H Kerns

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Binding: Hardcover
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Number of Pages: 549
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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization Télécharger Livres Gratuits

Druglike Properties Concepts Structure Design and Methods It can be correlated to various models of drug properties affecting ADMETox They include permeability absorption distribution plasma protein binding metabolism elimination and toxicity It often is an effective guide for modifying the structure of a lead series to improve a property DrugLike Properties Concept Structure Design and DrugLike Properties Concept Structure Design and Methods From ADME to Toxicity Optimization Biopharmaceutical classification system BCS The BCS classification system is based on the scientific rationale that if the highest dose of a drug candidate is readily soluble in the fluid volume on average present in the stomach 250 ml DrugLike Properties Concepts Structure Design and 353 IN VITRO TOXICITY METHODS As for other drug properties in vitro assays are applied for toxicity screening and measurement 2 This strategy allows drug discovery scientists to study a large number of compounds examine specific toxicity mechanisms 3 use a low amount of compound and reduce animal usage Druglike Properties Concepts acad Druglike Properties Concepts Structure Design and Methods Academic Press is an imprint of Elsevier 30 Corporate Drive Suite 400 Burlington MA 01803 USA 525 B Street Suite 1900 San Diego California 921014495 USA 84 Theobald’s Road London WC1X 8RR UK This book is printed on acidfree paper DrugLike Properties Concepts Structure Design and ContentsSummary DrugLike Properties Concepts Structure Design and Methods from ADME to Toxicity Optimization Second Edition provides scientists and students the background and tools to understand discover and develop optimal clinical candidates This valuable resource explores physiochemical properties including solubility and permeability DrugLike Properties 2nd Edition Elsevier DrugLike Properties Concepts Structure Design and Methods from ADME to Toxicity Optimization Second Edition provides scientists and students the background and tools to understand discover and develop optimal clinical candidates This valuable resource explores physiochemical properties including solubility and permeability before exploring how compounds are absorbed distributed and metabolized safely and stably

Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization Li Di, Edward H Kerns Télécharger Livres Gratuits